Many medications can cause side effects. Type the code shown: There are many forms of dystonia. Fatty acids and related: Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.
The body begins to essentially require the drug for normal function. Patients who do not continue to take clonazepam may grow violently ill as they experience the onset of a debilitating benzodiazepine withdrawal syndrome. Shakiness, shortness of breath, nausea and other physical effects may occur along with psychological effects such as mood swings, increased anxiety, agitation, and depression if a person abruptly stops taking clonazepam.
Abrupt cessation of benzodiazepines is never recommended, as seizure and convulsion may be the result—placing one's life in peril. When someone stops taking clonazepam they will experience a rebound effect. This means that the problems that the medication is designed to treat will present with great intensity and duration. If someone is using the medication to manage anxiety, anxious symptoms will reappear with increased worry, agitation, and nervousness.
To receive assistance with a sedative abuse disorder or to help someone dependent on clonazepam, call our helpline at Who Answers? Sudden withdrawal from clonazepam can be potentially life threatening due to the unwanted withdrawal symptoms. Sudden cessation of long-term clonazepam use can lead to marked agitation, neural excitation, and withdrawal seizure activity , so medical supervision is essential for someone looking to cease use of this drug.
Usually, patients go to a detox center for a period of time to gradually withdraw from the drug in a safe environment. Doctors at the detox center may give patients other medications or treatments to help with the uncomfortable physical effects of withdrawal from this drug. Medical supervision may also help manage psychological symptoms such as mood swings, hallucinations, and depression.
Rehab is usually focused on the psychological reasons for addiction and planning ways to live a happier life without use of the substance. Patients may receive individual and group therapy sessions as well become active participants in support group sessions, benefiting from the camaraderie and encouragement of others working through similar recovery issues. Patients live at the rehab facility with other people who are learning how to live without addictive substances.
Rehab may last anywhere from 30 days to one year, depending on a number of factors including severity of the addiction, progress in treatment, and outside supports. Outpatient programs allow the patient to return home and resume his or her normal activities while continuing to get treatment that could be daily, weekly, or less frequently based on their stage in recovery.
Outpatient programs are also options for those who are unable to attend an inpatient facility due to cost or other obligations. Rather than moving to an outpatient setting after rehab, some patients may choose to live in a sober living facility or halfway house upon completing treatment. These homes give patients some freedom. Patients usually have to work during the day and be home by a certain hour at night. They also have to follow house rules and submit to random drug testing to prove they are clean.
If you or someone you love is addicted to clonazepam, seek out the needed help. Please call Who Answers? It is possible to get off clonazepam and live a productive and happy life without the drug. Clonazepam Effects Quiz question 6. About Clonazepam Clonazepam, commonly known by its brand name Klonopin, is a prescription medication commonly used for its anti-anxiety and anti-convulsant benefits. This group includes substances like: Your information will be provided to a leading treatment center who is a paid sponsor of DrugAbuse.
Each year, the DrugAbuse. Suicide Prevention Lifeline - http: Your call is routed to the nearest crisis center in the national network of more than crisis centers. American Association of Poison Control Centers - http: Poison centers offer free, confidential medical advice 24 hours a day, seven days a week. Betty Ford Center - http: Phoenix House - http: Odyssey House - http: Recovery Gateway - http: Austin Recovery - http: Smart Recovery - http: Effects of Clonazepam Overdose Taking a higher dosage than prescribed, more frequently than prescribed, or taking a substance that is prescribed to someone else is an ill-advised, dangerous course of action that can lead to overdose.
Effects of benzodiazepine overdose can include: Loss of muscular coordination. Delirium or profound confusion. How Much is Too Much? The FAQ on Ativan. The data are also inconclusive on whether benzodiazepines such as clonazepam cause developmental deficits or decreases in IQ in the developing fetus when taken by the mother during pregnancy.
Clonazepam, when used late in pregnancy, may result in the development of a severe benzodiazepine withdrawal syndrome in the neonate. Withdrawal symptoms from benzodiazepines in the neonate may include hypotonia , apnoeic spells, cyanosis and impaired metabolic responses to cold stress. The safety profile of clonazepam during pregnancy is less clear than that of other benzodiazepines, and if benzodiazepines are indicated during pregnancy, chlordiazepoxide and diazepam may be a safer choice.
The use of clonazepam during pregnancy should only occur if the clinical benefits are believed to outweigh the clinical risks to the fetus. Caution is also required if clonazepam is used during breastfeeding. Possible adverse effects of use of benzodiazepines such as clonazepam during pregnancy include: Neonatal withdrawal syndrome associated with benzodiazepines include hypertonia , hyperreflexia , restlessness , irritability , abnormal sleep patterns, inconsolable crying, tremors or jerking of the extremities, bradycardia , cyanosis , suckling difficulties, apnea , risk of aspiration of feeds, diarrhea and vomiting, and growth retardation.
This syndrome can develop between 3 days to 3 weeks after birth and can have a duration of up to several months. The pathway by which clonazepam is metabolized is usually impaired in newborns. If clonazepam is used during pregnancy or breast feeding , it is recommended that serum levels of clonazepam are monitored and that signs of central nervous system depression and apnea are also checked for.
In many cases, non-pharmacological treatments, such as relaxation therapy, psychotherapy and avoidance of caffeine , can be an effective and safer alternative to the use of benzodiazepines for anxiety in pregnant women. Clonazepam acts by binding to the benzodiazepine site of the GABA receptors, which enhances the electric effect of GABA binding on neurons, resulting in an increased influx of chloride ions into the neurons. This further results in an inhibition of synaptic transmission across the central nervous system.
Benzodiazepines do not have any effect on the levels of GABA in the brain. Clonazepam does, however, affect glutamate decarboxylase activity. It differs from other anticonvulsant drugs it was compared to in a study. Benzodiazepines, including clonazepam, bind to mouse glial cell membranes with high affinity. This has been conjectured as a mechanism for high-dose effects on seizures in the study. Clonazepam is a chlorinated derivative of nitrazepam  and therefore a chloro-nitro benzodiazepine.
Clonazepam is lipid-soluble, rapidly crosses the blood—brain barrier , and penetrates the placenta. It is extensively metabolised into pharmacologically inactive metabolites. Clonazepam is metabolized extensively via nitroreduction by cytochrome P enzymes, including CYP3A4. Erythromycin , clarithromycin , ritonavir , itraconazole , ketoconazole , nefazodone , cimetidine , and grapefruit juice are inhibitors of CYP3A4 and can affect the metabolism of benzodiazepines.
In some individuals, however, peak blood concentrations were reached at 4—8 hours. Clonazepam passes rapidly into the central nervous system, with levels in the brain corresponding with levels of unbound clonazepam in the blood serum. Plasma levels of clonazepam can vary as much as tenfold between different patients.
Clonazepam is largely bound to plasma proteins. It is effective for 6—8 hours in children, and 6—12 in adults. A US government study of emergency department ED visits found that sedative-hypnotics were the most frequently implicated pharmaceutical drug in ED visits, with benzodiazepines accounting for the majority of these. Clonazepam was the second most frequently implicated benzodiazepine in ED visits. Alcohol alone was responsible for over twice as many ED visits than clonazepam in the same study.
The study examined the number of times the non-medical use of certain drugs was implicated in an ED visit. The criteria for non-medical use in this study were purposefully broad, and include, for example, drug abuse , accidental or intentional overdose , or adverse reactions resulting from legitimate use of the medication. Clonazepam was approved in the United States as a generic drug in and is now manufactured and marketed by several companies.
Clonazepam is available as tablets and orally disintegrating tablets wafers an oral solution drops , and as a solution for injection or intravenous infusion. From Wikipedia, the free encyclopedia. Not to be confused with clozapine , clonazolam , or clorazolam. D Evidence of risk. Class B1 Psychoactive drugs CA: Archived from the original on Retrieved Aug 15, Therapeutic uses of botulinum toxin. A Review of the Literature". The primary care companion for CNS disorders. A Historical Dictionary of Psychiatry.
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