Clonazepam dosage for sleep disorders

By | 23.05.2018

clonazepam dosage for sleep disorders

Klonopin , Klonopin Wafer. It kills the sex drive and so I try just half a tab a couple nights a week. All of us are different. My General Practitioner, my Psychologist, and NOW my Psychiatrist are all aware that I've been taking Clonazepam all this time, and they have never suggested I stop using it, because they can see especially my General Practitioner--who has been my doctor for over a decade the difference in me now. It was a retrospective analysis of case notes, and the numbers on each individual treatment were small.

Was prescribed: Clonazepam dosage for sleep disorders

Clonazepam dosage for sleep disorders 297
Clonazepam dosage for sleep disorders While dosage mechanism of action is unknown, it is thought possibly to reflect activity through noradrenergic and dopaminergic systems [ 76 ]. Sleep stages were disorders according to standard criteria clonazepam Rechtschaffen and Kales, I sure don't mind sacrificing sleep one night a month dosage the rest of the nights are good, sound sleep. I have been for it periodically when sleep for the past 10 clonazepam with breaks in sleep. If you look up the side effects it will say definitely not to be used for a sleep for. When I entered REM sleep they tell me that I started to ride my bike, so to speak, instead disorders acting out my dreams.
Clonazepam dosage for sleep disorders 386
Clonazepam dosage for sleep disorders 857

Going to google next, but would like to hear from anyone who has tried it. It has been very effective in reducing tremors and spasms and helps me sleep. It does seem to reduce dreaming or at least the recall of dreams. I think I will give it a try next week, if it doesn't help I can always go back. Seeing my Primary Care doctor this week and will get her opinion first. Took clonazepam klonipin for three years til I changed drs.

Talk to your dr. I also have REM sleep behavior disorder. I have had no negative side effects for the couple of years I've been on it. I understand it's for life, but so is PD and REM behavior disorder so I'm not considering how difficult it would be to stop it. When I entered REM sleep they tell me that I started to ride my bike, so to speak, instead of acting out my dreams. Your doctors right Clonazapan slows down the brain spasms that PD causes I just started taking it again what a relief I take it 2 times a day but I cut them in half and take it 4 times your next step is Xanax so be careful you don't want that was on that for7 yrs they detoxes me from that never been the same.

My Father has to take Clonazepam and Quetiapine to help with sleep and reliving his dreams. We cannot walk he can just support his own weight but his brain tells him he can stand to get out of bed. I recently started taking it at night for sleep disorder. I'm very sensitive to drugs so i cut mine in half, to even cutting that in half to take even less a dose and I feel more refreshed each morning.

My sleep is better and according to my other half, no thrashing or violence in my sleep. I started taking Cloneazepam in December after acting out violent dreams, talking in my sleep, and grabbing my wife's arm. It replaced the Xanax u was taking. U take clinazepam 2x at night. Jill warned me not to take Xanax while taking Clonazepam! My vivid dreams are gone and so is my acting.

She didn't exactly say but was very direct in not taking both. There might be some overdose possibilities. I see her tomorrow and get more information. Usually able to sleep in spite of severe ab pain and discomfort which is usually resolved by a good night's sleep. I have lovely vivid dreams, very pleasant. I don't know what REM sleep disorder is. I just couldn't fall asleep or stay asleep.

Thanks for everyone's input. Sounds like it is worth trying so I can sleep for more than 3 hours at a time. I have taken it for sleep for a several years per a different MD. He does not accept my insurance, had to change MD's, new MD will not prescribe it and seems totally unconcerned with sleep or withdrawal. Clonazepam, Benadryl or Tylenol PM and 6 mg of melatonin.

Not much sleep yet but may need a stronger dose, but I'll give it a little longer. The neurologist said not to just cut of Trazodone, doing it gradually. Have not had a problem with dreaming but it definitely works for the restless leg problems we both have. My wife has PD and takes three at bedtime. I only take one a bedtime but we both sleep like babies.

Great to hear such good news. I took the script to the pharmacy but due to bad weather in Maine, I'm waiting until tomorrow to pick it up. I'll be starting it tomorrow nite. It is also approved for treatment of typical and atypical absences, infantile myoclonic , myoclonic and akinetic seizures. The effectiveness of clonazepam in the short-term treatment of panic disorder has been demonstrated in controlled clinical trials.

Some long-term trials have suggested a benefit of clonazepam for up to three years without the development of tolerance but these trials were not placebo -controlled. Restless legs syndrome can be treated using clonazepam as a third-line treatment option as the use of clonazepam is still investigational. The long-term effects of clonazepam can include depression , [5] disinhibition , and sexual dysfunction.

Clonazepam, like other benzodiazepines, may impair a person's ability to drive or operate machinery. The central nervous system depressing effects of the drug can be intensified by alcohol consumption, and therefore alcohol should be avoided while taking this medication. Benzodiazepines have been shown to cause dependence.

Patients dependent on clonazepam should be slowly titrated off under the supervision of a qualified healthcare professional to reduce the intensity of withdrawal or rebound symptoms. Benzodiazepines such as clonazepam can be very effective in controlling status epilepticus , but, when used for longer periods of time, some potentially serious side-effects may develop, such as interference with cognitive functions and behavior.

Physiological dependence was demonstrated by flumazenil -precipitated withdrawal. A recurrence of symptoms of the underlying disease should be separated from withdrawal symptoms. Like all benzodiazepines, clonazepam is a GABA-positive allosteric modulator. High dosage and long-term use increase the risk and severity of dependence and withdrawal symptoms. Withdrawal seizures and psychosis can occur in severe cases of withdrawal, and anxiety and insomnia can occur in less severe cases of withdrawal.

A gradual reduction in dosage reduces the severity of the benzodiazepine withdrawal syndrome. Due to the risks of tolerance and withdrawal seizures, clonazepam is generally not recommended for the long-term management of epilepsies. Increasing the dose can overcome the effects of tolerance, but tolerance to the higher dose may occur and adverse effects may intensify.

The mechanism of tolerance includes receptor desensitization, down regulation, receptor decoupling, and alterations in subunit composition and in gene transcription coding. Tolerance to the anticonvulsant effects of clonazepam occurs in both animals and humans. In humans, tolerance to the anticonvulsant effects of clonazepam occurs frequently.

The degree of tolerance is more pronounced with clonazepam than with chlordiazepoxide. Abrupt or over-rapid withdrawal from clonazepam may result in the development of the benzodiazepine withdrawal syndrome, causing psychosis characterised by dysphoric manifestations, irritability, aggressiveness, anxiety, and hallucinations. Anti-epileptic drugs, benzodiazepines such as clonazepam in particular, should be reduced in dose slowly and gradually when discontinuing the drug to mitigate withdrawal effects.

Coma can be cyclic, with the individual alternating from a comatose state to a hyper-alert state of consciousness, which occurred in a 4-year-old boy who suffered an overdose of clonazepam. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, and fainting. Clonazepam and 7-aminoclonazepam may be quantified in plasma , serum or whole blood in order to monitor compliance in those receiving the drug therapeutically.

Results from such tests can be used to confirm the diagnosis in potential poisoning victims or to assist in the forensic investigation in a case of fatal overdosage. Both the parent drug and 7-aminoclonazepam are unstable in biofluids, and therefore specimens should be preserved with sodium fluoride, stored at the lowest possible temperature and analyzed quickly to minimize losses. The elderly metabolize benzodiazepines more slowly than younger individuals and are also more sensitive to the effects of benzodiazepines, even at similar blood plasma levels.

Doses for the elderly are recommended to be about half of that given to younger adults and are to be administered for no longer than two weeks. Long-acting benzodiazepines such as clonazepam are not generally recommended for the elderly due the risk of drug accumulation. The elderly are especially susceptible to increased risk of harm from motor impairments and drug accumulation side effects. Benzodiazepines also require special precaution if used by individuals that may be pregnant, alcohol- or drug-dependent, or may have comorbid psychiatric disorders.

Clonazepam is not recommended for use in those under Use in very young children may be especially hazardous. Of anticonvulsant drugs, behavioural disturbances occur most frequently with clonazepam and phenobarbital. Doses higher than 0. Clonazepam may aggravate hepatic porphyria. Clonazepam is not recommended for patients with chronic schizophrenia. A double-blinded, placebo-controlled study found clonazepam increases violent behavior in individuals with chronic schizophrenia.

Clonazepam has similar effectiveness to other benzodiazepines at often a lower dose. Clonazepam decreases the levels of carbamazepine , [87] [88] and, likewise, clonazepam's level is reduced by carbamazepine. Azole antifungals, such as ketoconazole , may inhibit the metabolism of clonazepam. Combined use of clonazepam with certain antidepressants , antiepileptics , such as phenobarbital , phenytoin and carbamazepine , sedative antihistamines , opiates , antipsychotics , nonbenzodiazepine hypnotics like zolpidem and alcohol may result in enhanced sedative effects.

There is some medical evidence of various malformations, e. The data are also inconclusive on whether benzodiazepines such as clonazepam cause developmental deficits or decreases in IQ in the developing fetus when taken by the mother during pregnancy. Clonazepam, when used late in pregnancy, may result in the development of a severe benzodiazepine withdrawal syndrome in the neonate. Withdrawal symptoms from benzodiazepines in the neonate may include hypotonia , apnoeic spells, cyanosis and impaired metabolic responses to cold stress.

The safety profile of clonazepam during pregnancy is less clear than that of other benzodiazepines, and if benzodiazepines are indicated during pregnancy, chlordiazepoxide and diazepam may be a safer choice. The use of clonazepam during pregnancy should only occur if the clinical benefits are believed to outweigh the clinical risks to the fetus. Caution is also required if clonazepam is used during breastfeeding. Possible adverse effects of use of benzodiazepines such as clonazepam during pregnancy include: Neonatal withdrawal syndrome associated with benzodiazepines include hypertonia , hyperreflexia , restlessness , irritability , abnormal sleep patterns, inconsolable crying, tremors or jerking of the extremities, bradycardia , cyanosis , suckling difficulties, apnea , risk of aspiration of feeds, diarrhea and vomiting, and growth retardation.

This syndrome can develop between 3 days to 3 weeks after birth and can have a duration of up to several months. The pathway by which clonazepam is metabolized is usually impaired in newborns. If clonazepam is used during pregnancy or breast feeding , it is recommended that serum levels of clonazepam are monitored and that signs of central nervous system depression and apnea are also checked for. In many cases, non-pharmacological treatments, such as relaxation therapy, psychotherapy and avoidance of caffeine , can be an effective and safer alternative to the use of benzodiazepines for anxiety in pregnant women.

Clonazepam acts by binding to the benzodiazepine site of the GABA receptors, which enhances the electric effect of GABA binding on neurons, resulting in an increased influx of chloride ions into the neurons. This further results in an inhibition of synaptic transmission across the central nervous system. Benzodiazepines do not have any effect on the levels of GABA in the brain.

Clonazepam does, however, affect glutamate decarboxylase activity. It differs from other anticonvulsant drugs it was compared to in a study. Benzodiazepines, including clonazepam, bind to mouse glial cell membranes with high affinity. This has been conjectured as a mechanism for high-dose effects on seizures in the study.

Clonazepam is a chlorinated derivative of nitrazepam [] and therefore a chloro-nitro benzodiazepine. Clonazepam is lipid-soluble, rapidly crosses the blood—brain barrier , and penetrates the placenta. It is extensively metabolised into pharmacologically inactive metabolites. Clonazepam is metabolized extensively via nitroreduction by cytochrome P enzymes, including CYP3A4. Erythromycin , clarithromycin , ritonavir , itraconazole , ketoconazole , nefazodone , cimetidine , and grapefruit juice are inhibitors of CYP3A4 and can affect the metabolism of benzodiazepines.

In some individuals, however, peak blood concentrations were reached at 4—8 hours. Clonazepam passes rapidly into the central nervous system, with levels in the brain corresponding with levels of unbound clonazepam in the blood serum. Plasma levels of clonazepam can vary as much as tenfold between different patients. Clonazepam is largely bound to plasma proteins.

It is effective for 6—8 hours in children, and 6—12 in adults. A US government study of emergency department ED visits found that sedative-hypnotics were the most frequently implicated pharmaceutical drug in ED visits, with benzodiazepines accounting for the majority of these. Clonazepam was the second most frequently implicated benzodiazepine in ED visits. Alcohol alone was responsible for over twice as many ED visits than clonazepam in the same study.

The study examined the number of times the non-medical use of certain drugs was implicated in an ED visit.


2 thoughts on “Clonazepam dosage for sleep disorders

  1. Makus

    I've been suffering from anxiety and panic disorder for a few months now. Primary care doctor tried a few different anti-depressants (Luvox, Wellbutrin, Zoloft...all generic forms) and I've had really bad side effects with them. He then suggested i see a psychopharmacologist(sp?), basically a psychiatrist who specializes in medications. After my first meeting with him he suggested Klonopin for my anxiety. Im to take that for a week, then when i go back, he wants to put me on a different anti-depressant to work hand in hand together. After about 4 days of taking 0.5mg x2 a day, i have to say i can say that i feel like a weight has been lifted off my shoulders. I wouldn't say that i am a 100% cured, but i feel as if i am on the right track. Only side effect so far has been a feeling of tiredness, but I dont mind so much because i never slept well to begin with. Overall, I'm happy with the medication, and i have a more positive outlook for the future.

  2. Muzragore

    I just started taking it so my body still has to adjust but I notice that I have gotten some sleep. I have an extremely important medical issues going on right now.

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