Doing so can provide you with more information about treatment options to lessen the impact of clonazepam in your life. About Anxiolytics Anxiolytics are used to prevent and treat symptoms of acute anxiety related to many conditions. Clonazepam passes rapidly into the central nervous system, with levels in the brain corresponding with levels of unbound clonazepam in the blood serum. This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. Follow the directions on your prescription label carefully. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen.
Clonazepam does, however, affect glutamate decarboxylase activity. It differs from other anticonvulsant drugs it was compared to in a study. Benzodiazepines, including clonazepam, bind to mouse glial cell membranes with high affinity. This has been conjectured as a mechanism for high-dose effects on seizures in the study. Clonazepam is a chlorinated derivative of nitrazepam  and therefore a chloro-nitro benzodiazepine.
Clonazepam is lipid-soluble, rapidly crosses the blood—brain barrier , and penetrates the placenta. It is extensively metabolised into pharmacologically inactive metabolites. Clonazepam is metabolized extensively via nitroreduction by cytochrome P enzymes, including CYP3A4. Erythromycin , clarithromycin , ritonavir , itraconazole , ketoconazole , nefazodone , cimetidine , and grapefruit juice are inhibitors of CYP3A4 and can affect the metabolism of benzodiazepines.
In some individuals, however, peak blood concentrations were reached at 4—8 hours. Clonazepam passes rapidly into the central nervous system, with levels in the brain corresponding with levels of unbound clonazepam in the blood serum. Plasma levels of clonazepam can vary as much as tenfold between different patients. Clonazepam is largely bound to plasma proteins. It is effective for 6—8 hours in children, and 6—12 in adults.
A US government study of emergency department ED visits found that sedative-hypnotics were the most frequently implicated pharmaceutical drug in ED visits, with benzodiazepines accounting for the majority of these. Clonazepam was the second most frequently implicated benzodiazepine in ED visits. Alcohol alone was responsible for over twice as many ED visits than clonazepam in the same study. The study examined the number of times the non-medical use of certain drugs was implicated in an ED visit.
The criteria for non-medical use in this study were purposefully broad, and include, for example, drug abuse , accidental or intentional overdose , or adverse reactions resulting from legitimate use of the medication. Clonazepam was approved in the United States as a generic drug in and is now manufactured and marketed by several companies. Clonazepam is available as tablets and orally disintegrating tablets wafers an oral solution drops , and as a solution for injection or intravenous infusion.
From Wikipedia, the free encyclopedia. Not to be confused with clozapine , clonazolam , or clorazolam. D Evidence of risk. Class B1 Psychoactive drugs CA: Archived from the original on Retrieved Aug 15, Therapeutic uses of botulinum toxin. A Review of the Literature". The primary care companion for CNS disorders. A Historical Dictionary of Psychiatry.
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Archived PDF from the original on The Annals of pharmacotherapy. The Cochrane Database of Systematic Reviews. What Can Go Wrong? American Psychiatric Publishing, Inc. Beware the sleeping pill hangover". Jeffrey; Nemeroff, Charles B. Principles of psychopharmacology for mental health professionals. Eur J Clin Pharmacol. Thrombocytopenia during treatment with clonazepam". No to Hattatsu in Japanese. A clinical long-term follow-up study". J Nerv Ment Dis. S Afr Med J. Journal of psychopharmacology Oxford, England.
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Bromide potassium bromide , sodium bromide Imepitoin Paraldehyde Stiripentol. Fatty acids and related: Valproate Valpromide Valproate pivoxil Vigabatrin. Progabide ; GAT-1 inhibitors: Ethotoin Fosphenytoin Mephenytoin Phenytoin ; Ureides: Valproate Valpromide Valproate pivoxil ; Carboxamides: Carbamazepine Eslicarbazepine acetate Oxcarbazepine ; Others: Lacosamide Lamotrigine Rufinamide Topiramate Zonisamide.
Ethadione Paramethadione Trimethadione ; Succinimides: Ethosuximide Mesuximide Phensuximide ; Gabapentinoids: Gabapentin Pregabalin ; Others: Imepitoin Lamotrigine Topiramate Zonisamide. To lower your risk, your doctor should have you take the smallest dose of clonazepam that works, and take it for the shortest possible time. Get medical help right away if any of these very serious side effects occur: Who should not take Clonazepam? Clonazepam is used to prevent and control seizures.
This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Clonazepam works by calming your brain and nerves. It belongs to a class of drugs called benzodiazepines. Read the Medication Guide provided by your pharmacist before you start taking clonazepam and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually 2 or 3 times daily. Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose, take it more often, or take it for a longer time than directed. Take this medication regularly to get the most benefit from it.
To help you remember, take it at the same times each day. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased. This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses.
To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away. When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well. Though it helps many people, this medication may sometimes cause addiction. Take this medication exactly as prescribed to lower the risk of addiction.
Ask your doctor or pharmacist for more details. If you have several different types of seizure disorders, you may experience a worsening of seizures when you first start using clonazepam. Consult your doctor right away if this happens. Your doctor may need to add or adjust the dose of your other medications to control the seizures. What conditions does Clonazepam treat? Drowsiness, dizziness , tiredness, loss of coordination, or increased saliva production may occur.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: Get medical help right away if you have any very serious side effects, including: A very serious allergic reaction to this drug is rare.
However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects.
You may report side effects to Health Canada at List Clonazepam side effects by likelihood and severity. Before taking clonazepam , tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines such as diazepam , lorazepam ; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication , tell your doctor or pharmacist your medical history, especially of: This drug may make you dizzy or drowsy.
Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs , nonprescription drugs, and herbal products.