Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. By clicking send, you acknowledge that you have permission to email the recipient with this information. Sign Up It's Free! If you log out, you will be required to enter your username and password the next time you visit. Brand and Other Names: Share Email Print Feedback Close. Essential Tremor Off-label 0. Burning Mouth Syndrome Off-label 0. Dosage Modifications Renal impairment: Supplemental dose in hemodialysis not necessary.
Dosing Considerations Discontinuation of treatment: Significant - Monitor Closely. All Interactions Sort By: Frequency Not Defined Increased salivation Worsening tonic-clonic seizures. Warnings Black Box Warnings Concomitant use of benzodiazepines and opioids may result in profound respiratory depression, coma, and death; administer concomitantly when there are no alternative options; limit dosages and durations to minimum required; monitor for signs and symptoms of respiratory depression and sedation.
Contraindications Significant hepatic impairment Documented hypersensitivity Acute narrow angle glaucoma. Lactation Effects on breastfed infant and on milk production are unknown; developmental and health benefits of breastfeeding should be considered along with mother's clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal condition. Pharmacology Mechanism of Action Long-acting benzodiazepine that increases the presynaptic GABA inhibition and reduces the monosynaptic and polysynaptic reflexes.
Suppresses muscle contractions by facilitating inhibitory GABA neurotransmission and other inhibitory transmitters Suppresses the spike-and-wave discharge in absence seizures by depressing nerve transmission in motor cortex. Print without Office Info. Print with Office Info. Formulary Formulary Patient Discounts. Create Your List of Plans. View explanations for tiers and restrictions. Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. Most commonly, these are "preferred" on formulary brand drugs.
Most commonly, these are "non-preferred" brand drugs. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. This restriction requires that specific clinical criteria be met prior to the approval of the prescription. QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
Non-Medicare Plans Medicare Plans. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. What would you like to print? Plasma concentrations of clonazepam were determined by electron-capture gas-liquid chromatography.
The absorption rates of clonazepam after i. Secondary plasma peaks of clonazepam were observed in 9 volunteers after i. A comparison of the area under the plasma concentration-time curves AUC shows that the i. Clonazepam was almost completely absorbed after i. No significant differences existed between the elimination half-lives i. In conclusion, the observed differences in C max and t max after i. The systemic exposure to clonazepam was not affected by the route of extravascular administration.
Statistical evaluation of these kinetic data showed differences in the absorption rate, so that clonazepam given by the i. On the basis of the results of this study, we would recommend the same i. Institutional Login Shibboleth or OpenAthens For the academic login, please select your country in the dropdown list. Sign up for MyKarger Institutional Login. Related Articles for " ". To view the fulltext, please log in. To view the pdf, please log in. Subscribe Access to all articles of the subscribed year s guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use You receive your access authorization within a few days; please copy this article reference into your MySelection.