Benzodiazepine addictions can be quite difficult to overcome, and can present health risks during the acute withdrawal period. There is a risk of overdose when abusing clonazepam. The medication is categorized as a benzodiazepine and classified as a Schedule IV controlled substance. Because clonazepam is a benzodiazepine drug, it is usually only prescribed by a doctor. Keep track of the amount of medicine used from each new bottle. Before taking clonazepam , tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines such as diazepam , lorazepam ; or if you have any other allergies. Talk to your doctor about the possible risks of using this medication for your condition.
Has clonazepam taken away the quality of your life or the life of someone you love? If you want lasting recovery, it is important to thoroughly research your treatment options and find rehabilitation that works. You may be surprised to learn about the many new treatment options and programs that are available for clonazepam and Klonopin dependence.
We offer a completely confidential and toll-free helpline that can help you find the treatment you need. Call us now to speak with an experienced recovery professional about your situation and find out more about the following:. Call for a confidential assessment Confidential and Private Call: What Clonazepam Addiction Does to a Person Sold under the brand name Klonopin, clonazepam is a powerful relaxant that is prescribed for anxiety , panic attacks and some seizure disorders.
Clonazepam is habit forming. This benzodiazepine drug is intended for short-term use. Many clonazepam users who continue to use this drug are forced to increase their dosage to maintain the original effects. Clonazepam users can develop a tolerance for very high doses of this drug. Clonazepam is not safer than street drugs. Many people mistakenly believe that this drug is safer than illegal street drugs, because it is available through medical channels.
Clonazepam is dangerous if taken incorrectly. If a user suddenly stops taking clonazepam, he or she may experience strong withdrawal symptoms that can range from panic attacks to serious health problems. It is important that any person who uses this drug seeks the help of a reputable detox program to quit. Of anticonvulsant drugs, behavioural disturbances occur most frequently with clonazepam and phenobarbital. Doses higher than 0. Clonazepam may aggravate hepatic porphyria. Clonazepam is not recommended for patients with chronic schizophrenia.
A double-blinded, placebo-controlled study found clonazepam increases violent behavior in individuals with chronic schizophrenia. Clonazepam has similar effectiveness to other benzodiazepines at often a lower dose. Clonazepam decreases the levels of carbamazepine ,   and, likewise, clonazepam's level is reduced by carbamazepine. Azole antifungals, such as ketoconazole , may inhibit the metabolism of clonazepam. Combined use of clonazepam with certain antidepressants , antiepileptics , such as phenobarbital , phenytoin and carbamazepine , sedative antihistamines , opiates , antipsychotics , nonbenzodiazepine hypnotics like zolpidem and alcohol may result in enhanced sedative effects.
There is some medical evidence of various malformations, e. The data are also inconclusive on whether benzodiazepines such as clonazepam cause developmental deficits or decreases in IQ in the developing fetus when taken by the mother during pregnancy. Clonazepam, when used late in pregnancy, may result in the development of a severe benzodiazepine withdrawal syndrome in the neonate.
Withdrawal symptoms from benzodiazepines in the neonate may include hypotonia , apnoeic spells, cyanosis and impaired metabolic responses to cold stress. The safety profile of clonazepam during pregnancy is less clear than that of other benzodiazepines, and if benzodiazepines are indicated during pregnancy, chlordiazepoxide and diazepam may be a safer choice. The use of clonazepam during pregnancy should only occur if the clinical benefits are believed to outweigh the clinical risks to the fetus.
Caution is also required if clonazepam is used during breastfeeding. Possible adverse effects of use of benzodiazepines such as clonazepam during pregnancy include: Neonatal withdrawal syndrome associated with benzodiazepines include hypertonia , hyperreflexia , restlessness , irritability , abnormal sleep patterns, inconsolable crying, tremors or jerking of the extremities, bradycardia , cyanosis , suckling difficulties, apnea , risk of aspiration of feeds, diarrhea and vomiting, and growth retardation.
This syndrome can develop between 3 days to 3 weeks after birth and can have a duration of up to several months. The pathway by which clonazepam is metabolized is usually impaired in newborns. If clonazepam is used during pregnancy or breast feeding , it is recommended that serum levels of clonazepam are monitored and that signs of central nervous system depression and apnea are also checked for.
In many cases, non-pharmacological treatments, such as relaxation therapy, psychotherapy and avoidance of caffeine , can be an effective and safer alternative to the use of benzodiazepines for anxiety in pregnant women. Clonazepam acts by binding to the benzodiazepine site of the GABA receptors, which enhances the electric effect of GABA binding on neurons, resulting in an increased influx of chloride ions into the neurons.
This further results in an inhibition of synaptic transmission across the central nervous system. Benzodiazepines do not have any effect on the levels of GABA in the brain. Clonazepam does, however, affect glutamate decarboxylase activity. It differs from other anticonvulsant drugs it was compared to in a study. Benzodiazepines, including clonazepam, bind to mouse glial cell membranes with high affinity.
This has been conjectured as a mechanism for high-dose effects on seizures in the study. Clonazepam is a chlorinated derivative of nitrazepam  and therefore a chloro-nitro benzodiazepine. Clonazepam is lipid-soluble, rapidly crosses the blood—brain barrier , and penetrates the placenta. It is extensively metabolised into pharmacologically inactive metabolites.
Clonazepam is metabolized extensively via nitroreduction by cytochrome P enzymes, including CYP3A4. Erythromycin , clarithromycin , ritonavir , itraconazole , ketoconazole , nefazodone , cimetidine , and grapefruit juice are inhibitors of CYP3A4 and can affect the metabolism of benzodiazepines. In some individuals, however, peak blood concentrations were reached at 4—8 hours.
Clonazepam passes rapidly into the central nervous system, with levels in the brain corresponding with levels of unbound clonazepam in the blood serum. Plasma levels of clonazepam can vary as much as tenfold between different patients. Clonazepam is largely bound to plasma proteins. It is effective for 6—8 hours in children, and 6—12 in adults. A US government study of emergency department ED visits found that sedative-hypnotics were the most frequently implicated pharmaceutical drug in ED visits, with benzodiazepines accounting for the majority of these.
Clonazepam was the second most frequently implicated benzodiazepine in ED visits. Alcohol alone was responsible for over twice as many ED visits than clonazepam in the same study. The study examined the number of times the non-medical use of certain drugs was implicated in an ED visit. The criteria for non-medical use in this study were purposefully broad, and include, for example, drug abuse , accidental or intentional overdose , or adverse reactions resulting from legitimate use of the medication.
Clonazepam was approved in the United States as a generic drug in and is now manufactured and marketed by several companies. Clonazepam is available as tablets and orally disintegrating tablets wafers an oral solution drops , and as a solution for injection or intravenous infusion. From Wikipedia, the free encyclopedia. Not to be confused with clozapine , clonazolam , or clorazolam. D Evidence of risk. Class B1 Psychoactive drugs CA: Archived from the original on Retrieved Aug 15, Therapeutic uses of botulinum toxin.
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